Lazio v Red Bull Salzburg, 05 April 2018
| Score | 4-2 to Lazio |
| Referee | Ovidiu HaĊ£egan |
| Competition | UEFA Europa League Quarter-final 1st leg |
| Venue | Stadio Olimpico, Rome |
| Attendance | 42,538 |
Kick-off: 9.05pm local
4 Lazio
Manager: Simone Inzaghi
2 Red Bull Salzburg
Manager: Marco Rose