Lazio v Olympique Marseille, 21 October 2021
| Score | 0-0 |
| Referee | Deniz Aytekin |
| Competition | UEFA Europa League Group E |
| Venue | Stadio Olimpico, Rome |
| Attendance | 8,329 |
Kick-off: 6.45pm local
0 Lazio
Manager: Maurizio Sarri
0 Olympique Marseille
Manager: Jorge Sampaoli