Lazio v Lokomotiv Moscow, 30 September 2021
| Score | 2-0 to Lazio |
| Referee | Craig Pawson |
| Competition | UEFA Europa League Group E |
| Venue | Stadio Olimpico, Rome |
| Attendance | 6,767 |
Kick-off: 9.00pm local
2 Lazio
Manager: Maurizio Sarri
0 Lokomotiv Moscow
Manager: Marko Nikolić