Lazio v FC Porto, 24 February 2022
| Score | 2-2 |
| Referee | Deniz Aytekin |
| Competition | UEFA Europa League Play-off 2nd leg |
| Venue | Stadio Olimpico, Rome |
| Attendance | 24,948 |
Kick-off: 6.45pm local
FC Porto won 4-3 on aggregate
2 Lazio
Manager: Maurizio Sarri
2 FC Porto
Manager: Sérgio Conceição