Internazionale v Shakhtar Donetsk, 24 November 2021
| Score | 2-0 to Internazionale |
| Referee | Ovidiu HaĊ£egan |
| Competition | UEFA Champions League Group D |
| Venue | San Siro, Milan |
| Attendance | 46,225 |
Kick-off: 6.45pm local
2 Internazionale
Manager: Simone Inzaghi
0 Shakhtar Donetsk
Manager: Roberto De Zerbi