Internazionale v Real Madrid, 15 September 2021
| Score | 1-0 to Real Madrid |
| Referee | Daniel Siebert |
| Competition | UEFA Champions League Group D |
| Venue | San Siro, Milan |
| Attendance | 37,082 |
Kick-off: 9.00pm local
0 Internazionale
Manager: Simone Inzaghi
1 Real Madrid
Manager: Carlo Ancelotti