| Score | 6-0 to Guyana |
| Referee | Sergio Rozenhout |
| Competition | CONCACAF Nations League League B Group D |
| Venue | Estadio Olímpico Félix Sánchez, Santo Domingo |
View Guyana v Antigua and Barbuda head to head
Manager: Jamaal Shabazz
| Kelsey Benjamin | 7 |
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| Omari Glasgow | 36 |
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| Nathan Moriah-Welsh | 45 |
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| Osaze De Rosario | 67 |
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| Leo-orion Lovell | 90 |
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| Deon Moore | 90+3 |
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| Osaze De Rosario for Omari Glasgow | 46 |
| Leo-orion Lovell for Jonathan Grant | 55 |
| Kadell Daniel for Daniel Wilson | 69 |
| Deon Moore for Kelsey Benjamin | 69 |
| Marcus Simmons for Colin Nelson | 75 |
| Jonathan Grant | 41 | Y |
Manager: Mikele Leigertwood
| Vashami Allen for Aaron Taylor-Sinclair | 46 |
| Kendukar Challenger for Quinton Griffith | 46 |
| Shevorn Phillip for Cardel Roberts | 46 |
| Kwame Kirby for Dion Pereira | 71 |
| Josh Parker for Ashley Nathaniel-George | 79 |
| Aaron Taylor-Sinclair | 23 | Y |