| Score | 3-0 to Guinea Bissau |
| Referee | Tewodros Mitiku |
| Competition | Africa Cup of Nations Qualifying group L |
| Venue | Estádio 24 de Setembro, Bissau |
View Guinea Bissau v Nigeria head to head
Manager: Emiliano Té
| Franculino Djú | 15 |
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| Mama Baldé | 66 |
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| Álvaro Djaló | 90+5 |
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| Mamadi Camará for Renato Nhaga | 61 |
| Alfa Semedo for Ronaldo Vieira Nan | 71 |
| Mauro Rodrigues for Mama Baldé | 71 |
| Álvaro Djaló for Beto | 79 |
| Tamble for Franculino Djú | 79 |
| Opa Sangante | 75 | Y |
| Alfa Semedo | 88 | Y |
Manager: Éric Chelle
| Moses Simon for Taiwo Awoniyi | 46 |
| Moses Usor for Frank Onyeka | 46 |
| Tolu Arokodare for Ademola Lookman | 68 |
| George Ilenikhena for Akor Adams | 76 |
| Raphael Onyedika for Wilfred Ndidi | 76 |
| Calvin Bassey | 90+3 | Y |