Galatasaray v Lazio, 16 September 2021
| Score | 1-0 to Galatasaray |
| Referee | Matej Jug |
| Competition | UEFA Europa League Group E |
| Venue | Türk Telekom Stadium, Istanbul |
| Attendance | 15,353 |
Kick-off: 7.45pm local
1 Galatasaray
Manager: Fatih Terim
0 Lazio
Manager: Maurizio Sarri