FC Sheriff Tiraspol v Shakhtar Donetsk, 15 September 2021
| Score | 2-0 to FC Sheriff Tiraspol |
| Referee | Deniz Aytekin |
| Competition | UEFA Champions League Group D |
| Venue | Sheriff Stadium, Tiraspol |
| Attendance | 5,205 |
Kick-off: 7.45pm local
2 FC Sheriff Tiraspol
Manager: Yuriy Vernydub
0 Shakhtar Donetsk
Manager: Roberto De Zerbi