FC Porto v Olympique Lyonnais, 09 March 2022
| Score | 1-0 to Olympique Lyonnais |
| Referee | José María Sánchez |
| Competition | UEFA Europa League Round of 16 1st leg |
| Venue | Estádio do Dragão, Porto |
| Attendance | 26,309 |
Kick-off: 5.45pm local
0 FC Porto
Manager: Sérgio Conceição
1 Olympique Lyonnais
Manager: Peter Bosz