FC Porto v Lazio, 17 February 2022
| Score | 2-1 to FC Porto |
| Referee | Serdar Gözübüyük |
| Competition | UEFA Europa League Play-off 1st leg |
| Venue | Estádio do Dragão, Porto |
| Attendance | 32,929 |
Kick-off: 8.00pm local
2 FC Porto
Manager: Sérgio Conceição
1 Lazio
Manager: Maurizio Sarri