FC Porto v AC Milan, 19 October 2021
| Score | 1-0 to FC Porto |
| Referee | Felix Brych |
| Competition | UEFA Champions League Group B |
| Venue | Estádio do Dragão, Porto |
| Attendance | 32,130 |
Kick-off: 8.00pm local
1 FC Porto
Manager: Sérgio Conceição
0 AC Milan
Manager: Stefano Pioli