Eintracht Frankfurt v Real Betis, 17 March 2022
| Score | 1-1 |
| Referee | Michael Oliver |
| Competition | UEFA Europa League Round of 16 2nd leg |
| Venue | Deutsche Bank Park, Frankfurt |
| Attendance | 25,000 |
Kick-off: 9.00pm local
Eintracht Frankfurt won 3-2 on aggregate
After extra time - 0-1 at 90 minutes
1 Eintracht Frankfurt
Manager: Oliver Glasner
1 Real Betis
Manager: Manuel Pellegrini