Benfica v Barcelona, 29 September 2021
| Score | 3-0 to Benfica |
| Referee | Daniele Orsato |
| Competition | UEFA Champions League Group E |
| Venue | Estádio da Luz, Lisbon |
| Attendance | 29,454 |
Kick-off: 8.00pm local
3 Benfica
Manager: Jorge Jesus
0 Barcelona
Manager: Ronald Koeman