Bayer Leverkusen v Villarreal, 17 March 2016
| Score | 0-0 |
| Referee | Willie Collum |
| Competition | UEFA Europa League Round of 16 2nd leg |
| Venue | BayArena, Leverkusen |
| Attendance | 16,211 |
Villarreal won 2-0 on aggregate.
Kick-off: 7.00pm local (6.00pm GMT)
0 Bayer Leverkusen
Manager: Roger Schmidt
Starting lineup:
Goalkeeper
Bernd Leno
Defender
Kyriakos Papadopoulos
Defender
Jonathan Tah
Defender
Wendell
Midfielder
Karim Bellarabi
Midfielder
Julian Brandt
Midfielder
Marlon Frey
Midfielder
Hakan Çalhanoğlu
(captain)
Midfielder
Christoph Kramer
Forward
Javier Hernández
Forward
Admir Mehmedi
Substitutions:
| Robbie Kruse for Admir Mehmedi | 59 |
| Vladlen Yurchenko for Christoph Kramer | 68 |
| Andre Ramalho for Kyriakos Papadopoulos | 79 |
Cards:
| Admir Mehmedi | 42 | Y |
| Kyriakos Papadopoulos | 73 | Y |
| Karim Bellarabi | 78 | Y |
On the bench:
Goalkeeper
Dario Kresic
Defender
Joel Abu Hanna
Defender
Lukas Boeder
Defender
Andre Ramalho
Defender/Midfielder
Benjamin Henrichs
Midfielder
Vladlen Yurchenko
Midfielder/Forward
Robbie Kruse
0 Villarreal
Manager: Marcelino
Starting lineup:
Sergio Asenjo
Goalkeeper
Eric Bailly
Defender
Mario
Defender
Victor Ruiz
Defender
Antonio Rukavina
Defender
Bruno Soriano
Midfielder
(captain)
Tomas Pina
Midfielder
Denis Suárez
Midfielder
Cédric Bakambu
Forward
Samu Castillejo
Forward
Soldado
Forward
Substitutions:
| Manu Trigueros for Samu Castillejo | 61 |
| Adrian Lopez for Soldado | 74 |
| Alfonso Pedraza for Denis Suárez | 89 |
Cards:
| Antonio Rukavina | 60 | Y |
| Cédric Bakambu | 80 | Y |
On the bench:
Goalkeeper
Mariano Barbosa
Defender
Daniele Bonera
Defender
Adrian Marin
Midfielder
Alfonso Pedraza
Midfielder
Manu Trigueros
Forward
Adrian Lopez
Forward
Nahuel