Bayer Leverkusen v Real Betis, 04 November 2021
| Score | 4-0 to Bayer Leverkusen |
| Referee | Anthony Taylor |
| Competition | UEFA Europa League Group G |
| Venue | BayArena, Leverkusen |
| Attendance | 15,208 |
Kick-off: 9.00pm
4 Bayer Leverkusen
Manager: Gerardo Seoane
0 Real Betis
Manager: Manuel Pellegrini