Bayer Leverkusen v Atletico Madrid, 13 September 2022
| Score | 2-0 to Bayer Leverkusen |
| Referee | Michael Oliver |
| Competition | UEFA Champions League Group B |
| Venue | BayArena, Leverkusen |
| Attendance | 25,825 |
Kick-off: 9.00pm local
2 Bayer Leverkusen
Manager: Gerardo Seoane
0 Atletico Madrid
Manager: Diego Simeone