AS Roma v Vitesse Arnhem, 17 March 2022
| Score | 1-1 |
| Referee | Radu Petrescu |
| Competition | UEFA Europa Conference League Round of 16 2nd leg |
| Venue | Stadio Olimpico, Rome |
| Attendance | 40,435 |
Kick-off: 9.00pm local
AS Roma won 2-1 on aggregate
1 AS Roma
Manager: José Mourinho
1 Vitesse Arnhem
Manager: Thomas Letsch