AS Roma v Shakhtar Donetsk, 11 March 2021
| Score | 3-0 to AS Roma |
| Referee | Artur Dias |
| Competition | UEFA Europa League Round of 16 1st leg |
| Venue | Stadio Olimpico, Rome |
Kick-off: 9.00pm local
Played behind closed doors due to COVID-19 restrictions.
3 AS Roma
Manager: Paulo Fonseca
0 Shakhtar Donetsk
Manager: Luís Castro