AS Roma v Real Betis, 06 October 2022
| Score | 2-1 to Real Betis |
| Referee | Matej Jug |
| Competition | UEFA Europa League Group C |
| Venue | Stadio Olimpico, Rome |
| Attendance | 62,294 |
Kick-off: 9.00pm local
1 AS Roma
Manager: José Mourinho
2 Real Betis
Manager: Manuel Pellegrini