AS Roma v CSKA Sofia, 16 September 2021
| Score | 5-1 to AS Roma |
| Referee | Glenn Nyberg |
| Competition | UEFA Europa Conference League Group C |
| Venue | Stadio Olimpico, Rome |
| Attendance | 29,876 |
Kick-off: 9.00pm local
5 AS Roma
Manager: José Mourinho
1 CSKA Sofia
Manager: Stoycho Mladenov