AS Roma v Ajax, 15 April 2021
| Score | 1-1 |
| Referee | Anthony Taylor |
| Competition | UEFA Europa League Quarter-final 2nd leg |
| Venue | Stadio Olimpico, Rome |
Kick-off: 9.00pm local
AS Roma won 3-2 on aggregate.
Played behind closed doors due to COVID-19 restrictions.
1 AS Roma
Manager: Paulo Fonseca
1 Ajax
Manager: Erik Ten Hag