Anderlecht v APOEL Nicosia, 16 March 2017
| Score | 1-0 to Anderlecht |
| Referee | Aleksei Kulbakov |
| Competition | UEFA Europa League Round of 16 2nd leg |
| Venue | Constant Vanden Stock, Anderlecht |
| Attendance | 15,662 |
Kick-off: 9.05pm local (8.05pm GMT)
Anderlecht won 2-0 on aggregate.
1 Anderlecht
Manager: René Weiler
0 APOEL Nicosia
Manager: Thomas Christiansen