Anderlecht v 1.FSV Mainz 05, 03 November 2016
| Score | 6-1 to Anderlecht |
| Referee | Andreas Ekberg |
| Competition | UEFA Europa League Group C |
| Venue | Constant Vanden Stock, Anderlecht |
Kick-off: 7.00pm local (6.00pm GMT)
6 Anderlecht
Manager: Rene Weiler
1 1.FSV Mainz 05
Manager: Martin Schmidt