Ajax v Sporting Clube Portugal, 07 December 2021
| Score | 4-2 to Ajax |
| Referee | Davide Massa |
| Competition | UEFA Champions League Group C |
| Venue | Johan Cruyff ArenA, Amsterdam |
Kick-off: 9.00pm local
Played behind closed doors due to COVID-19 restrictions.
4 Ajax
Manager: Erik Ten Hag
2 Sporting Clube Portugal
Manager: Rúben Amorim