Ajax v Napoli, 04 October 2022
| Score | 6-1 to Napoli |
| Referee | François Letexier |
| Competition | UEFA Champions League Group A |
| Venue | Johan Cruyff ArenA, Amsterdam |
| Attendance | 52,896 |
Kick-off: 9.00pm local
1 Ajax
Manager: Alfred Schreuder
6 Napoli
Manager: Luciano Spalletti