Ajax v Borussia Dortmund, 19 October 2021
| Score | 4-0 to Ajax |
| Referee | Jesús Gil Manzano |
| Competition | UEFA Champions League Group C |
| Venue | Johan Cruyff ArenA, Amsterdam |
| Attendance | 54,029 |
Kick-off: 9.00pm local
4 Ajax
Manager: Erik Ten Hag
0 Borussia Dortmund
Manager: Marco Rose