Ajax v Benfica, 15 March 2022
| Score | 1-0 to Benfica |
| Referee | Carlos Del Cerro Grande |
| Competition | UEFA Champions League Round of 16 2nd leg |
| Venue | Johan Cruyff ArenA, Amsterdam |
| Attendance | 54,066 |
Kick-off: 9.00pm local
Benfica won 3-2 on aggregate
0 Ajax
Manager: Erik ten Hag
1 Benfica
Manager: Nélson Verissimo