Ajax v AS Roma, 08 April 2021
| Score | 2-1 to AS Roma |
| Referee | Sergei Karasev |
| Competition | UEFA Europa League Quarter-final 1st leg |
| Venue | Johan Cruyff ArenA, Amsterdam |
Kick-off: 9.00pm local
Played behind closed doors due to COVID-19 restrictions.
1 Ajax
Manager: Erik Ten Hag
2 AS Roma
Manager: Paulo Fonseca