AC Milan v Real Betis, 25 October 2018
| Score | 2-1 to Real Betis |
| Referee | Bas Nijhuis |
| Competition | UEFA Europa League Group F |
| Venue | San Siro, Milan |
| Attendance | 22,405 |
Kick-off: 6.55pm local (5.55pm BST)
1 AC Milan
Manager: Gennaro Gattuso
2 Real Betis
Manager: Quique Setién