AC Milan v Atlético Madrid, 28 September 2021
| Score | 2-1 to Atlético Madrid |
| Referee | Cüneyt Çakir |
| Competition | UEFA Champions League Group B |
| Venue | San Siro, Milan |
| Attendance | 35,374 |
Kick-off: 9.00pm local
1 AC Milan
Manager: Stefano Pioli
2 Atlético Madrid
Manager: Diego Simeone