| Score | 3-2 to Leyton Orient |
| Referee | Andy Woolmer |
| Competition | League Two |
| Venue | Kassam Stadium |
| Attendance | 12,243 |
View Oxford United v Leyton Orient head to head
| Eric Sabin | 14 |
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| Chris Willmott | 66 |
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| Steve Basham for Eric Sabin | 69 |
| Jamie Brooks for Lee Mansell | 76 |
| Billy Beechers for Jay Smith | 89 |
| John Dempster | 33 | Y |
| Chris Willmott | 85 | R |
| Craig Easton | 17 |
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| Gary Alexander | 64 |
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| Lee Steele | 90 |
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| Shane Tudor for Joe Keith | 79 |
| Jabo Ibehre for Wayne Corden | 82 |
| Daryl McMahon for Michael Simpson | 87 |
| John Mackie | 86 | Y |
| Gabby Zakuani | 88 | Y |
Comments:
Final 2005-06 League position: 23rd Unused substitutes: Chris Tardif and Tim Sills This result confirmed Oxford United's relegation to the Conference, so returning to non-league football after 44 years.Comments:
Final 2005-06 League position: 3rd Unused substitutes: Glenn Morris and Donny Barnard This result confirmed Leyton Orient's promotion to League One